Pentamidine congeners 1: Synthesis of Cis- and Trans-butamidine analogues as anti-Pneumocystis carinii pneumonia agents.

Bioorganic & Medicinal Chemistry Letters
1993.0

Abstract

Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pneumonia activity in a rat model of the disease.

DOI： 10.1016/S0960-894X(00)80302-9

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