Optically active fluorinated cyclobutane nucleoside analogs with potent anti-herpes activity

Bioorganic & Medicinal Chemistry Letters
1993.0

Abstract

The synthesis and antiherpes activity of several optically active 4'-fluoro-2',3'-dihydroxymethylcyclobutyl nucleoside analogs are described. A key synthetic step is the diastereoselective [2+2] cycloaddition of a novel fluoroketene acetal with (-)-dimenthyl fumarate.

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