Synthesis and antitumor evaluation of 2′-oxycarbonylpaclitaxels (paclitaxel-2′-carbonates)

Bioorganic & Medicinal Chemistry Letters
1994.0

Abstract

A number of 2'-oxycarbonylpaclitaxels (paclitaxel-2'-carbonates) 3 have been prepared and evaluated for their cytotoxicity and in vivo antitumor activity. Most of these paclitaxel-2'-carbonates were found to exhibit in vivo antitumor activity in the i.p. M109 murine tumor model system, comparable to that of the parent drug.

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