Synthesis of biologically active 2-benzoyl paclitaxel analogues

Bioorganic & Medicinal Chemistry Letters
1995.0

Abstract

The influence of aromatic substitution at the 2-benzoyl moiety of paclitaxel on biological activity was investigated, following the Topliss Operational Scheme. Twelve paclitaxel derivatives were synthesized and evaluated in a microtubule assembly assay and for cytotoxicity against B16 melanoma cells. Most of the analogues were found to possess biological properties similar to paclitaxel.

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