Design, synthesis and evaluation of dual domain FKBP ligands

Design, synthesis and evaluation of dual domain FKBP ligands Structure-activity studies of synthetic FKBP ligands as peptidyl-prolyl isomerase inhibitors The affinity of the excised binding domain of FK-506 for the immunophilin FKBP12. One-step Heck Reaction Generates Nonimmunosuppressive FK506 Analogs for Pharmacological BMP Activation Meridamycin: A novel nonimmunosuppressive FKBP12 ligand from streptomyces hygroscopicus Structure-activity studies of nonmacrocyclic rapamycin derivatives Synthesis of FK506-Cyclosporin hybrid macrocycles 32-Ascomycinyloxyacetic Acid Derived Immunosuppressants. Independence of Immunophilin Binding and Immunosuppressive Potency The Precise Chemical–Physical Nature of the Pharmacore in FK506 Binding Protein Inhibition: ElteX, a New Class of Nanomolar FKBP12 Ligands Novel derivatives at the C21 position of the FK-506 macrocycle