Novel derivatives at the C21 position of the FK-506 macrocycle

Novel derivatives at the C21 position of the FK-506 macrocycle Preparation and in vitro activity of aryl ether derivatives of the FK-506 related immunosuppressive macrolides ascomycin and L-683,742 Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin) C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity Alkyl ether analogs of the FK-506 related, immunosuppressive macrolide L-683,590 (ascomycin) Meridamycin: A novel nonimmunosuppressive FKBP12 ligand from streptomyces hygroscopicus Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity Chemical and Biological Characterization of Two FK506 Analogs Produced by Targeted Gene Disruption in Streptomyces sp. MA6548. Design, synthesis and evaluation of dual domain FKBP ligands