Novel angiotensin converting enzyme inhibitors containing α-hydroxy ketomethylene dipeptide isosteres

Bioorganic & Medicinal Chemistry Letters
1994.0

Abstract

Synthesis of novel angiotensin converting enzyme inhibitors has been accomplished using the a-hydroxy ketomethylene dipeptide isostere as a key constituent. (2R, 5s )-2 hydroxy-5-benzamido-4-oxo-6-phenyl hexanoyl (S )-(-)-indoline-2-carboxylic acid (7) showed potent inhibitory activity against angiotensin converting enzyme. IC, = 0.09 pM.

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