Diaryl phosphate derivatives act as pro-drugs of AZT with reduced cytotoxicity compared to the parent nucleoside

Diaryl phosphate derivatives act as pro-drugs of AZT with reduced cytotoxicity compared to the parent nucleoside Aryl phosphate derivates of AZT inhibit HIV replication in cells where the nucleoside is poorly active Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells Aryl Phosphoramidate Derivatives of d4T Have Improved Anti-HIV Efficacy in Tissue Culture and May Act by the Generation of a Novel Intracellular Metabolite Uncharged AZT and D4T Derivatives of Phosphonoformic and Phosphonoacetic Acids as Anti-HIV Pronucleosides S-Acyl-2-thioethyl Phosphoramidate Diester Derivatives as Mononucleotide Prodrugs Aryl nucleoside H-phosphonates. Part 16: Synthesis and anti-HIV-1 activity of di-aryl nucleoside phosphotriesters Anti-HIV pronucleotides: Decomposition pathways and correlation with biological activities S-Acyl-2-Thioethyl Aryl Phosphotriester Derivatives of AZT:  Synthesis, Antiviral Activity, and Stability Study