Design and synthesis of new leads for PKC bisubstrate inhibitors.

Design and synthesis of new leads for PKC bisubstrate inhibitors. Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides 2-aryl-indolyl maleimides - novel and potent inhibitors of protein kinase C Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ Synthesis of anilino-monoindolylmaleimides as potent and selective PKCβ inhibitors Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3 Protein kinase C-α inhibitors; structure-activity relationships in bis-indole series Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C