2-aryl-indolyl maleimides - novel and potent inhibitors of protein kinase C

2-aryl-indolyl maleimides - novel and potent inhibitors of protein kinase C Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides Design and synthesis of new leads for PKC bisubstrate inhibitors. Novel indolocarbazole protein kinase c inhibitors with improved biochemical and physicochemical properties Protein kinase C-α inhibitors; structure-activity relationships in bis-indole series Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ Synthesis of anilino-monoindolylmaleimides as potent and selective PKCβ inhibitors