Macrolide-type motilin receptor agonists: Acid-stable 12-O-methyl-8,9-anhydroerythromycin A 6,9-hemiacetals

Bioorganic & Medicinal Chemistry Letters
1995.0

Abstract

Based on the acid decomposition mechanism of erythromycin A, 12-O-methyl-8,9 anhydroerythromycin A 6,9-hemiacetals were designed and synthesized. These compounds were acidstable and showed potent in vitro and in vivo motilin agonistic activities, and were thought to be promising orally active prokinetic agents.

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