Preparation of 9-deoxo-4″-deoxy-6,9-epoxyerythromycin lactams “motilactides”: Potent and orally active prokinetic agents

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

A series of new, highly potent and orally active "motilactides", 9-deoxo-4"-deoxy-6,9-epoxyerythromycin lactams was designed, synthesized, and evaluated for their gastrointestinal motor stimulating activity. These compounds were acid stable and showed good oral efficacy.

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