Application of the “trimethyl lock”1 to Ganciclovir, a pro-prodrug with increased oral bioavailability

Application of the “trimethyl lock”1 to Ganciclovir, a pro-prodrug with increased oral bioavailability Synthesis and Evaluation of 2-Amino-9-(1,3-dihydroxy-2-propoxymethyl)- 6-fluoropurine Mono- and Diesters as Potential Prodrugs of Ganciclovir Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) Ester Prodrugs of Cyclic 1-(S)- [3-Hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine:  Synthesis and Antiviral Activity Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug Synthesis and antiviral activity of acyclovir-5′-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug N,N′-Dihydroxyamidines: A New Prodrug Principle To Improve the Oral Bioavailability of Amidines