Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro-quinolone-3-carboxylic acids

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

New racemic N•(••azifidin•).6.flu•r••7.(4•methy•piperazin•••y•).4(•H).quin•••ne•3.•arboxy•ic acids (9a-i) were ~ynthesized and their antibacterial activities were tested against Gram-positive and Gramnegative micro-organisms. According to the MIC, all compounds studied are less active than Ciprofloxacin; two of them (ga,b) have similar activity as Nalidixic acid (1).

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