2-aminoalchohol immunosuppressants: Structure-activity relationships

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

The 2-aminoalcohol series of immunosuppressants showed a bell-shaped relationship between the activity and the carbon number. The (R)-isomers were more potent than the (S) isomers, and (R)-2-aminohexadecanol displayed comparably activity to a potent immunosuppressant, FTY720.

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