Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

Desymmerization of symmetric FTY720 by substitution of different alkyl groups for one of the prochiral hydroxymethyl groups was performed. The size of the alkyl groups and the absolute configuration at quaternary carbon were important on immunosuppressive activity.

Knowledge Graph

Similar Paper

Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols
Journal of Medicinal Chemistry 2000.0
Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720
Bioorganic & Medicinal Chemistry Letters 1995.0
2-aminoalchohol immunosuppressants: Structure-activity relationships
Bioorganic & Medicinal Chemistry Letters 1996.0
2-Substituted 2-aminoethanol: Minimum essential structure for immunosuppressive activity of ISP-I (Myriocin)
Bioorganic & Medicinal Chemistry Letters 1995.0
Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer
Journal of Medicinal Chemistry 2005.0
Design, Synthesis, and Antileukemic Activity of Stereochemically Defined Constrained Analogues of FTY720 (Gilenya)
ACS Medicinal Chemistry Letters 2013.0
TX-2152: A conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity
Bioorganic & Medicinal Chemistry 2008.0
Stereochemistry–activity relationship of orally active tetralin S1P agonist prodrugs
Bioorganic & Medicinal Chemistry Letters 2010.0
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: Discovery of potent S1P1 receptor agonists
Bioorganic & Medicinal Chemistry Letters 2005.0