Small peptidic aldehyde inhibitors of human rhinovirus 3C protease

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Small peptide aldehydes were designed to mimic the preferred substrate requirements for the human rhinovirus 3C protease. Di- and tripeptide aldehydes containing a methionine sulfone as a Pt surrogate for glutamine show low micromolar enzyme inhibitory and antiviral tissue culture activity. LY338387, obtained in a short and efficient synthesis, appears to validate the protease as a therapeutic target.

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