The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Three 4-thiazolidinone libraries, each containing up to 540 compounds, were prepared and assayed for inhibition of the enzyme cyclooxygenase-1 (COX-l). Deconvolution analysis led to the identification of a compound that is equipotent with the commercial COX- 1 inhibitors ibuprofen and phenylbutazone.

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