SYNTHESIS AND ANTISTAPHYLOCOCCAL ACTIVITY OF NEMATOPHIN AND ITS ANALOGS

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

Nematophin, a novel antibiotic from Xenorhabdus nematophilus, and its analogs were synthesized, and their biological activity was evaluated. It was demonstrated that the conjugated carbonyl acyl group in nematophin and its analogs is essential for their antistaphylococcal bioactivity.

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