Identification of novel (isoxazole)methylene-1-azabicyclic compounds with high affinity for the central nicotinic cholinergic receptor

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

A novel class of compounds with high affinity (IC50 = 3.4 - 500 nM) for the central nicotinic cholinergic receptor was synthesized. The compounds were characterized in vitro and in vivo and compared to ABT 418 and nicotine. The new ligands are effective nicotinic compounds with biological profiles distinguishable from reference compounds.

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