BN 80245: An E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

The crucial E-ring of camptothecin has been modified to afford the homologous β-hydroxylactone derivative BN 80245. This compound, which is more stable than camptothecin, remains a potent inhibitor of both cell growth and topoisomerase I. © 1997 Elsevier Science Ltd.

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