Covalent binding of catechols to src family SH2 domains
Bioorganic & Medicinal Chemistry Letters
1997.0
Abstract
Src family SH2 domains contain an uncoupled cysteine residue, that, when arylated with air oxidized catechols, inhibits the protein from binding to otherwise high affinity peptide ligands. No inhibition is observed for Crk, Abl, or Grb2 SH2 domains.