Rapid decomposition of peroxynitrite by manganese porphyrin-antioxidant redox couples

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

Mn(III)TMPyP reacts rapidly with the toxic oxidant peroxynitrite (ONOO-)to generate an oxoMn0V) species, but Mn(I]I)TMPyP is not catalytic for ONOO- decomposition due to the slow reduction of oxoMn(IV) back to the Mn(HI) oxidation state. However, when redox-coupled with biological antioxidants that efficiently reduce oxoMn(IV), Mn(~I)TMPyP is transformed into an efficient "peroxynitrite reductase."

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