Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite

MedChemComm
2018.0

Abstract

<i>S</i>-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O<sub>2</sub>˙<sup>-</sup> promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO<sup>-</sup>). Since the production of O<sub>2</sub>˙<sup>-</sup> can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in medicine.

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