Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.

Knowledge Graph

Similar Paper

Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and structure–activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2015.0
Synthesis of Conformationally Constrained Analogues of Linezolid:  Structure−Activity Relationship (SAR) Studies on Selected Novel Tricyclic Oxazolidinones
Journal of Medicinal Chemistry 2002.0
Synthesis and antibacterial activity of oxazolidinones containing triazolyl group
European Journal of Medicinal Chemistry 2007.0
Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure–activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones
Bioorganic & Medicinal Chemistry Letters 2006.0
Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties
Bioorganic & Medicinal Chemistry Letters 2008.0
Conformational Constraint in Oxazolidinone Antibacterials. Synthesis and Structure−Activity Studies of (Azabicyclo[3.1.0]hexylphenyl)oxazolidinones
Journal of Medicinal Chemistry 2005.0
Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones
European Journal of Medicinal Chemistry 2008.0
Synthesis and in vitro antibacterial activities of novel oxazolidinones☆
European Journal of Medicinal Chemistry 2008.0
Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid
Bioorganic & Medicinal Chemistry Letters 2006.0