Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure–activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

A new class of oxazolidinone antibacterials incorporating oxygen-, nitrogen-, or sulfur-containing heterobicyclic C-rings is described. The in vitro potency and in vivo efficacy of these conformationally constrained oxazolidinone analogs are discussed.

Knowledge Graph

Similar Paper

Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure–activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones
Bioorganic & Medicinal Chemistry Letters 2006.0
Conformational Constraint in Oxazolidinone Antibacterials. Synthesis and Structure−Activity Studies of (Azabicyclo[3.1.0]hexylphenyl)oxazolidinones
Journal of Medicinal Chemistry 2005.0
Synthesis and Structure−Activity Relationship Studies of Highly Potent Novel Oxazolidinone Antibacterials
Journal of Medicinal Chemistry 2008.0
Potent Oxazolidinone Antibacterials with Heteroaromatic C-Ring Substructure
ACS Medicinal Chemistry Letters 2013.0
Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones
Bioorganic & Medicinal Chemistry Letters 1998.0
Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure
ACS Medicinal Chemistry Letters 2017.0
Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 1: Substituted pyrazoles
Bioorganic & Medicinal Chemistry Letters 2007.0
Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and SAR of novel conformationally restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system
Bioorganic & Medicinal Chemistry Letters 2007.0
Synthesis and structure–activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2006.0