Synthesis and biological properties of new 1β-methylcarbapenems

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2 = NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety.

DOI： 10.1016/s0960-894x(98)00270-4

Knowledge Graph

Similar Paper

Synthesis and biological properties of new 1β-methylcarbapenems
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and biological activity of 1β-methyl-2-[5′-isoxazoloethenylpyrrolidin-3′-ylthio]carbapenems
Bioorganic & Medicinal Chemistry Letters 2000.0
Studies on β-lactam antibiotics. Synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs
Bioorganic & Medicinal Chemistry Letters 1997.0
Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety
Bioorganic & Medicinal Chemistry Letters 2000.0
Synthesis and biological evaluation of novel 1β-methylcarbapenems with isothiazoloethenyl side chains
Bioorganic & Medicinal Chemistry Letters 2003.0
Novel 1β-methylcarbapenems with isoxazoloethenyl moieties containing carboxylic acid sodium salt
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis and biological evaluation of novel 1β-methylcarbapenems having a new moiety at C-2
Bioorganic & Medicinal Chemistry Letters 1999.0
Synthesis and biological activity of novel 1β-Methylcarbapenems with oxyiminopyrrolidinylamide moiety
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and antibacterial activity of FR21818, a new, potent 1β-methylcarbapenem
Bioorganic & Medicinal Chemistry Letters 1995.0
Synthesis and biological properties of new 1β-methylcarbapenems having tetrazolothioether moiety
Bioorganic & Medicinal Chemistry Letters 2000.0