Studies on β-lactam antibiotics. Synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

The synthesis and biological activity of the novel series of llknethylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-I stability. The best compound in this series, IX21818 (la) displayed excellent in vivo efficacy against an MRSA infection in mice.

DOI： 10.1016/S0960-894X(97)00230-8

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