Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.

Knowledge Graph

Similar Paper

Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and Structure−Activity Relationships of 2-Pyridones:  A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents
Journal of Medicinal Chemistry 1996.0
Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and antibacterial activity of a new series of tetracyclic pyridone carboxylic acids
Journal of Medicinal Chemistry 1993.0
Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains
Journal of Medicinal Chemistry 1993.0
Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids
Journal of Medicinal Chemistry 1988.0
Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors
Bioorganic & Medicinal Chemistry Letters 2007.0
Fluoronaphthyridines and -quinolones as antibacterial agents. 5. Synthesis and antimicrobial activity of chiral 1-tert-butyl-6-fluoro-7-substituted-naphthyridones
Journal of Medicinal Chemistry 1992.0
Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents
Journal of Medicinal Chemistry 1987.0
Synthesis and antibacterial activity of a new series of tetracyclic pyridone carboxylic acids. 2
Journal of Medicinal Chemistry 1993.0