Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

A series of 3-hydroxyquinazoline-2,4-diones was synthesized and evaluated for antibacterial activity. This series represents a novel addition to the DNA gyrase inhibitor class of antibacterials. Appropriate substitutions onto the core template yielded compounds with excellent potency against E. coli gyrase and significant in vitro Gram-negative and Gram-positive antibacterial activity.

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