Macrolide biosynthesis: A single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae

Macrolide biosynthesis: A single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae Isolation and Structure Determination of Novamethymycin, a New Bioactive Metabolite of the Methymycin Biosynthetic Pathway in Streptomyces venezuelae Neopikromycin and Novapikromycin from the Pikromycin Biosynthetic Pathway of <i>Streptomyces </i><i>v</i><i>enezuelae</i> Neopikromycin and Novapikromycin from the Pikromycin Biosynthetic Pathway of <i>Streptomyces </i><i>v</i><i>enezuelae</i> Isolation and Structure Determination of Novamethymycin, a New Bioactive Metabolite of the Methymycin Biosynthetic Pathway in <i>Streptomyces </i><i>v</i><i>enezuelae</i> A gene cluster for macrolide antibiotic biosynthesis in <i>Streptomyces venezuelae</i> : Architecture of metabolic diversity Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis Genome Mining of the Biosynthetic Gene Cluster of the Polyene Macrolide Antibiotic Tetramycin and Characterization of a P450 Monooxygenase Involved in the Hydroxylation of the Tetramycin B Polyol Segment