Isolation and Structure Determination of Novamethymycin, a New Bioactive Metabolite of the Methymycin Biosynthetic Pathway in Streptomyces venezuelae

Isolation and Structure Determination of Novamethymycin, a New Bioactive Metabolite of the Methymycin Biosynthetic Pathway in Streptomyces venezuelae Isolation and Structure Determination of Novamethymycin, a New Bioactive Metabolite of the Methymycin Biosynthetic Pathway in <i>Streptomyces </i><i>v</i><i>enezuelae</i> Neopikromycin and Novapikromycin from the Pikromycin Biosynthetic Pathway of <i>Streptomyces </i><i>v</i><i>enezuelae</i> Neopikromycin and Novapikromycin from the Pikromycin Biosynthetic Pathway of <i>Streptomyces </i><i>v</i><i>enezuelae</i> Macrolide biosynthesis: A single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae A gene cluster for macrolide antibiotic biosynthesis in <i>Streptomyces venezuelae</i> : Architecture of metabolic diversity New methymycin derivatives of Streptomyces venezuelae ATCC 15439 and their inhibitory effects on human T cell proliferation mediated by PMA/ionomycin New methymycin derivatives of Streptomyces venezuelae ATCC 15439 and their inhibitory effects on human T cell proliferation mediated by PMA/ionomycin Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis