Thio-sugars IV: Design and synthesis of S-linked fucoside analogs as a new class of α-L-fucosidase inhibitors

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

alpha-1-Thio-L-fucose derivative 4 and 5 as new alpha-fucosidase inhibitors (K1 = 4.6, and 5.9 microM) have been synthesized in three steps by base catalyzed coupling with bromonitromethane followed by reduction of the nitro group with sodium borohydride/cobalt chloride complex and acetylation.

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