Asymmetric synthesis of the l-fuco-nojirimycin, a nanomolar α-l-fucosidase inhibitor
Bioorganic & Medicinal Chemistry Letters
2006.0
Abstract
We describe the asymmetric synthesis of the 5-amino-5-deoxy-l-fucose (l-fuco-nojirimycin) which appears as a very potent fucosidase inhibitor with a K(i) value of 1 nM.