A paclitaxel analogue with a 2(3→20)abeotaxane skeleton: Synthesis and biological evaluation

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

A paclitaxel analogue having an unusual tricyclic [9.3.1.1] hexadecane skeleton was synthesized from deaminoacyltaxine A, a 2(3-->20) abeotaxane isolated in considerable amounts from the leaves of Taxus baccata L. In preliminary studies, this compound showed a much lower cytotoxicity than paclitaxel.

Knowledge Graph

Similar Paper