4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation

4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-3′-phenylisoserinate) and Baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-chlorophenyl)isoserinate) The first synthesis of a C-9 carbonyl modified baccatin III derivative and its conversion to novel taxol® and taxotere® analogues Structure-Activity Studies of Antitumor Taxanes: Synthesis of Novel C-13 Side Chain Homologated Taxol and Taxotere Analogs Synthesis of novel taxol analogs and evaluation of their biological activities Semisynthesis and biological activity of taxol analogues: baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-tolyl)isoserinate), baccatin III 13-(N-(p-toluoyl)-2′R,3′S)-3′-phenylisoserinate), baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-trifluoromethylphenyl)isoserinate), and baccatin III 13-(N-(p-trifluoromethylbenzoyl)-(2′R,3′S)-3′-phenylisoserinate) Synthesis and biological activity of 3′-alkyl- and 3′-alkenyl-3′-dephenyldocetaxels Synthesis and biological activity of 14-hydroxydocetaxel Relationships between the structure of taxol analogs and their antimitotic activity Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5′-hydroxybutitaxel