Adenosine-5′-carboxylic acid peptidyl derivatives as inhibitors of protein kinases

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

A new class of protein kinase bisubstrate-analog inhibitors was designed on the basis of adenosine-5'-carboxylic acid derivatives, where a short peptide was attached to the 5'-carbon atom of the adenosine sugar moiety via a linker chain. The potency and selectivity of these inhibitors were adjusted by relevant combination of these structural fragments, resembling the structure of the bisubstrate complex of the peptide phosphorylation reaction.

Knowledge Graph

Similar Paper

Adenosine-5′-carboxylic acid peptidyl derivatives as inhibitors of protein kinases
Bioorganic & Medicinal Chemistry Letters 1999.0
Adenine-arginine mimetics as bisubstrate analog inhibitors of cAMP-dependent protein kinase
Bioorganic & Medicinal Chemistry Letters 1996.0
Synthesis and Biological Testing of Purine Derivatives as Potential ATP-Competitive Kinase Inhibitors
Journal of Medicinal Chemistry 2005.0
Species- or isozyme-specific enzyme inhibitors. 9. Selective effects in inhibitions of rat pyruvate kinase isozymes by adenosine 5'-diphosphate derivatives
Journal of Medicinal Chemistry 1982.0
Design of substrate-site-directed irreversible inhibitors of adenosine 5'-phosphate aminohydrolase. Effect of substrate substituents on affinity for the substrate site
Journal of Medicinal Chemistry 1976.0
Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5'-phosphate derivatives
Journal of Medicinal Chemistry 1982.0
Design and synthesis of new leads for PKC bisubstrate inhibitors.
Bioorganic & Medicinal Chemistry Letters 1994.0
New inhibitors of platelet aggregation. 5'-Phosphate, 5'-phosphorothioate, and 5'-O-sulfamoyl derivatives of 2-substituted adenosine analogs
Journal of Medicinal Chemistry 1978.0
Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase
Journal of Medicinal Chemistry 1990.0
Species- or isozyme-selective enzyme inhibitors. 8. Synthesis of disubstituted two-substrate condensation products as inhibitors of rat adenylate kinases
Journal of Medicinal Chemistry 1982.0