3-Alkyl-(5,5′-diphenyl)imidazolidinediones as new cannabinoid receptor ligands

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.

Knowledge Graph

Similar Paper

3-Alkyl-(5,5′-diphenyl)imidazolidinediones as new cannabinoid receptor ligands
Bioorganic & Medicinal Chemistry Letters 1999.0
Substituted 5,5‘-Diphenyl-2-thioxoimidazolidin-4-one as CB<sub>1</sub> Cannabinoid Receptor Ligands:  Synthesis and Pharmacological Evaluation
Journal of Medicinal Chemistry 2005.0
Synthesis and Activity of 1,3,5-Triphenylimidazolidine-2,4-diones and 1,3,5-Triphenyl-2-thioxoimidazolidin-4-ones: Characterization of New CB<sub>1</sub> Cannabinoid Receptor Inverse Agonists/Antagonists
Journal of Medicinal Chemistry 2006.0
Novel sterically hindered cannabinoid CB1 receptor ligands
Bioorganic &amp; Medicinal Chemistry 2008.0
1-Benzhydryl-3-phenylurea and 1-Benzhydryl-3-phenylthiourea Derivatives:  New Templates among the CB<sub>1</sub> Cannabinoid Receptor Inverse Agonists
Journal of Medicinal Chemistry 2005.0
Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors
Bioorganic &amp; Medicinal Chemistry Letters 2013.0
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB 1 receptor ligand antagonists
Bioorganic &amp; Medicinal Chemistry 2018.0
Discovery of 1,1-dioxo-1,2,6-thiadiazine-5-carboxamide derivatives as cannabinoid-like molecules with agonist and antagonist activity
Bioorganic &amp; Medicinal Chemistry 2007.0
Substituted 2-Thioxoimidazolidin-4-ones and Imidazolidine-2,4-diones as Fatty Acid Amide Hydrolase Inhibitors Templates
Journal of Medicinal Chemistry 2006.0
Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists
Bioorganic &amp; Medicinal Chemistry Letters 2010.0