RNA-aminoglycoside antibiotic interactions: Fluorescence detection of binding and conformational change

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

A hammerhead ribozyme has been labeled with a fluorescein reporter dye which enables the nucleic acid to detect binding of small organic compounds such as neomycin. The fluorescent changes are associated with conformational changes in the RNA and can be used to determine the binding modes of the drugs.

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