Homoisofagomines: Chemical-enzymatic synthesis and evaluation as α- and β-glucosidase inhibitors
Bioorganic & Medicinal Chemistry Letters
1999.0
Abstract
Methyl- and hydroxymethyl derivatives of the highly potent glycosidase inhibitor isofagomine are accessible via aldolase-catalyzed C-C bond formation and competitively inhibit beta-glucosidase at low micromolar concentrations.