Homoisofagomines: Chemical-enzymatic synthesis and evaluation as α- and β-glucosidase inhibitors

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Methyl- and hydroxymethyl derivatives of the highly potent glycosidase inhibitor isofagomine are accessible via aldolase-catalyzed C-C bond formation and competitively inhibit beta-glucosidase at low micromolar concentrations.

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