Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: Ion-dipole interactions with lysine 60G

Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: Ion-dipole interactions with lysine 60G From natural products to achiral drug prototypes: Potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs Preparation of l-proline based aeruginosin 298-A analogs: Optimization of the P1-moiety Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors DERIVATIVES OF 4-AMINO-PYRIDINE AS SELECTIVE THROMBIN INHIBITORS Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis How a Fragment Draws Attention to Selectivity Discriminating Features between the Related Proteases Trypsin and Thrombin Synthesis of 2-guanidinyl pyridines and their trypsin inhibition and docking Active site-directed plasmin inhibitors: Extension on the P2 residue Role of the Hydrogen Bonding Heteroatom−Lys53 Interaction between the p38α Mitogen-Activated Protein (MAP) Kinase and Pyridinyl-Substituted 5-Membered Heterocyclic Ring Inhibitors