Synthesis and structure–activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1- hi ]indoles: novel PDE4 inhibitors

Synthesis and structure–activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1- hi ]indoles: novel PDE4 inhibitors Synthesis, Structure−Activity Relationships, and Pharmacological Profile of 9-Amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indoles:  Discovery of Potent, Selective Phosphodiesterase Type 4 Inhibitors Design and synthesis of 4,5,6,7‐tetrahydro‐1 H ‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors Novel indolizine compounds as potent inhibitors of phosphodiesterase IV (PDE4): structure–activity relationship Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors Synthesis of 2H- 1,3-benzoxazin-4(3 H )-one derivatives containing indole moiety: Their in vitro evaluation against PDE4B N-Arylrolipram derivatives as potent and selective PDE4 inhibitors Novel Selective PDE4 Inhibitors. 2. Synthesis and Structure−Activity Relationships of 4-Aryl-Substituted cis-Tetra- and cis-Hexahydrophthalazinones Design, synthesis and in vitro PDE4 inhibition activity of certain quinazolinone derivatives for treatment of asthma Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors