Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors

Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors Orally active indole N-oxide PDE4 inhibitors The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I Synthesis, Structure−Activity Relationships, and Pharmacological Profile of 9-Amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indoles:  Discovery of Potent, Selective Phosphodiesterase Type 4 Inhibitors Novel indolizine compounds as potent inhibitors of phosphodiesterase IV (PDE4): structure–activity relationship Synthesis and structure–activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1- hi ]indoles: novel PDE4 inhibitors Rhodanine derivatives as novel inhibitors of PDE4 The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles