First pharmacophoric hypothesis for 5-HT 7 antagonism

First pharmacophoric hypothesis for 5-HT 7 antagonism Optimization of the Pharmacophore Model for 5-HT₇R Antagonism. Design and Synthesis of New Naphtholactam and Naphthosultam Derivatives Pharmacophore identification of α1A-adrenoceptor antagonists Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site Synthesis, Molecular Modeling Studies, and Pharmacological Activity of Selective A₁Receptor Antagonists Characterization of the 5-HT₇Receptor. Determination of the Pharmacophore for 5-HT₇Receptor Agonism and CoMFA-Based Modeling of the Agonist Binding Site Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation Computer-Aided Design and Synthesis of 5-Substituted Tryptamines and Their Pharmacology at the 5-HT1D Receptor: Discovery of Compounds with Potential Anti-Migraine Properties Pharmacophore modeling and virtual screening for designing potential 5-Lipoxygenase inhibitors Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT 7 receptor agents with antidepressant activity