Synthesis and structure–activity relationships of novel fungal chitin synthase inhibitors

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

A novel Candida albicans chitin synthase 1 (CaChs1) inhibitor, RO-41-0986 (1) was discovered by random screening. Systematic modification led to the identification of a highly potent CaChs1 inhibitor, RO-09-3024 (2), having strong antifungal activity against Candida spp. in vitro.

Knowledge Graph

Similar Paper

Synthesis and structure–activity relationships of novel fungal chitin synthase inhibitors
Bioorganic & Medicinal Chemistry Letters 2000.0
Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N -myristoyltransferase. Part 1
Bioorganic & Medicinal Chemistry Letters 2001.0
Sesquiterpene Furan Compound CJ-01, a Novel Chitin Synthase 2 Inhibitor from Chloranthus japonicus SIEB.
Biological and Pharmaceutical Bulletin 2008.0
Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents
European Journal of Medicinal Chemistry 2019.0
Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents
European Journal of Medicinal Chemistry 2016.0
FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No. 11243. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties.
The Journal of Antibiotics 2000.0
Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents
European Journal of Medicinal Chemistry 2020.0
Design, synthesis and biological evaluation of novel diazaspiro[4.5]decan-1-one derivatives as potential chitin synthase inhibitors and antifungal agents
European Journal of Medicinal Chemistry 2019.0
Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents
Bioorganic & Medicinal Chemistry 2014.0
Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3′-quinolin]-2′-one derivatives as potential chitin synthase inhibitors and antifungal agents
European Journal of Medicinal Chemistry 2022.0