Selective α1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

A series of alpha1a receptor antagonists derived from a 4-aryl-3,4-dihydropyridine-2-one heterocycle is disclosed. Potency in the low nanomolar to picomolar range along with high selectivity was obtained. In vivo efficacy in a prostate contraction model in rats was observed with a few derivatives.

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