Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule.

Knowledge Graph

Similar Paper

Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors
Bioorganic & Medicinal Chemistry Letters 2000.0
Bicyclo[3.2.1]octanes: Synthesis and inhibition of binding at the dopamine and serotonin transporters
Bioorganic & Medicinal Chemistry Letters 1999.0
Synthesis and dopamine transporter binding affinities of 3α-Benzyl-8-(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes
Bioorganic & Medicinal Chemistry Letters 2002.0
Synthesis and biological activity of 2-Carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and Pharmacology of Site Specific Cocaine Abuse Treatment Agents:  8-Substituted Isotropane (3-Azabicyclo[3.2.1]octane) Dopamine Uptake Inhibitors
Journal of Medicinal Chemistry 2003.0
Synthesis and Pharmacology of Site-Specific Cocaine Abuse Treatment Agents:  2-Substituted-6-amino-5-phenylbicyclo[2.2.2]octanes
Journal of Medicinal Chemistry 1999.0
Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and Dopamine Transporter Affinity of the Four Stereoisomers of (±)-2-(Methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane
Journal of Medicinal Chemistry 1998.0
Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine
Bioorganic & Medicinal Chemistry Letters 2000.0
The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes
Bioorganic & Medicinal Chemistry Letters 2011.0