Synthesis and biological property of carba and 20-Deoxo analogues of arenastatin A

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized. Both analogues lacking the 15,20-ester function, which was easily metabolized in serum, showed good stability in serum as well as moderate cytotoxic activity against KB cells and better solubility.

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