l-selenohomocysteine: one-step synthesis from l-selenomethionine and kinetic analysis as substrate for methionine synthases

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

A single-step convenient synthesis of L-selenohomocysteine (SeHcy) from L-selenomethionine (SeMet) using sodium in liquid ammonia is described. Methionine synthases convert SeHcy to SeMet at rates comparable to their rates of conversion of L-homocysteine (Hcy) to L-methionine (Met). This study suggests that SeHcy generated from SeMet metabolism can be efficiently recycled to SeMet in mammals.

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