Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABAA receptor

Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABAA receptor Synthesis and pharmacological evaluation of .gamma.-aminobutyric acid analogs. New ligand for GABAB sites Developing dual functional allosteric modulators of GABAA receptors Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABAA receptors 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies Activation of the γ-Aminobutyric Acid Type B (GABA_B) Receptor by Agonists and Positive Allosteric Modulators Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists Phosphinic Acid Analogs of GABA. 1. New Potent and Selective GABAB Agonists Hydroxy-1,2,5-oxadiazolyl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Pharmacological Characterization of γ-Aminobutyric Acid (GABA) Related Compounds A Novel Class of Potent 3-Isoxazolol GABA_AAntagonists:  Design, Synthesis, and Pharmacology